ABSTRACT
Malignant nodular hidradenomas are rare variants of sweat gland carcinomas characterized by aggressive clinical behaviour. We report a case of 42-year-old female with 3 x 2 x 1 cm nodule on her foot followed by cutaneous and regional lymph node metastasis. Flow cytometry showed S-phase fraction of 72.6% and 15.8% of aneuploid cells corroborating with its aggressive nature.
Subject(s)
Adenoma, Sweat Gland/diagnosis , Aneuploidy , Humans , Lymph Nodes/pathology , Lymphatic Metastasis , Skin Neoplasms/secondary , Sweat Gland Neoplasms/diagnosisABSTRACT
Cystic fibrosis (CF) is the most common potentially lethal disorder of Caucassians. Its frequency in India is not known. We diagnosed 30 cases of CF based on sweat chloride testing. The clinical profile and frequency of delta F508 mutation was studied. The frequency of F508 mutation was 27% (16 chromosomes) which is much lower as compared to that patients in the Western world. Eight patients carried other mutations, three of them were new mutations.